Tesamorelin vs. Sermorelin
Head-to-head comparison based on the profiles in the PepCycle library.
| Attribute | Tesamorelin | Sermorelin |
|---|---|---|
| Class | Growth Hormone | Growth Hormone |
| Description | Tesamorelin is a synthetic analog of human growth hormone–releasing hormone (GHRH) and is FDA-approved for the reduction of excess visceral adipose tissue in adults with HIV-associated lipodystrophy. Beyond its approved indication, it has been investigated in metabolic, hepatic, and cognitive research contexts. Educational reference only; not medical advice. | A synthetic 29-amino acid peptide corresponding to the first 29 amino acids of naturally occurring GHRH. |
| Dose in studies | 1-2 mg per day | 200-500 mcg before bed |
| Frequency | Daily | Nightly before bed |
| Half-life | 26-38 minutes | 10-20 minutes |
| Cycle length | Continuous under medical supervision | 3-6 months on, 1-3 months off |
| Research level | 4/5 – Well researched | 3/5 – Moderate research |
Tesamorelin: full profile · Sermorelin: full profile
Values from research literature – not medical advice.