SS-31 vs. NAD+ 500mg
Head-to-head comparison based on the profiles in the PepCycle library.
| Attribute | SS-31 | NAD+ 500mg |
|---|---|---|
| Class | Mitochondrial | Longevity |
| Description | A cell-permeable peptide that targets cardiolipin in the inner mitochondrial membrane to reduce oxidative damage. | Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in every living cell. Supplementation via injection restores declining NAD+ levels associated with aging, supporting cellular energy production, DNA repair, sirtuin activation, and neuroprotection. |
| Dose in studies | 10-40 mg per day | 50-500 mg per injection (SubQ/IM). IV: 250-500 mg over 2-4 hours. Start low and titrate up. |
| Frequency | Daily | 1-3x per week (SubQ/IM) or 1-2x per month (IV) |
| Half-life | 1-2 hours | IV infusion: immediate bioavailability | IM/SubQ: variable, ~1-4 hours absorption | Intracellular NAD+ half-life: ~1-2 hours |
| Cycle length | 4-12 weeks based on indication | Continuous protocol with periodic loading phases. 8-12 weeks standard, re-evaluate. |
| Research level | 3/5 – Moderate research | 3/5 – Moderate research |
SS-31: full profile · NAD+ 500mg: full profile
Values from research literature – not medical advice.