Ipamorelin vs. Sermorelin
Head-to-head comparison based on the profiles in the PepCycle library.
| Attribute | Ipamorelin | Sermorelin |
|---|---|---|
| Class | Growth Hormone Peptides | Growth Hormone |
| Description | A selective growth hormone secretagogue that stimulates GH release without significantly affecting cortisol or prolactin levels. | A synthetic 29-amino acid peptide corresponding to the first 29 amino acids of naturally occurring GHRH. |
| Dose in studies | 200-300 mcg 2-3x daily | 200-500 mcg before bed |
| Frequency | 2-3x daily | Nightly before bed |
| Half-life | ~2-3 hours | 10-20 minutes |
| Cycle length | 8-16 weeks on, 4-8 weeks off | 3-6 months on, 1-3 months off |
| Research level | 2/5 – Limited research | 3/5 – Moderate research |
Ipamorelin: full profile · Sermorelin: full profile
Values from research literature – not medical advice.