Epithalon vs. NAD+ 500mg
Head-to-head comparison based on the profiles in the PepCycle library.
| Attribute | Epithalon | NAD+ 500mg |
|---|---|---|
| Class | Anti-Aging Peptides | Longevity |
| Description | A synthetic tetrapeptide based on epithalamin, a naturally occurring pineal gland peptide. Researched for telomerase activation properties. | Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in every living cell. Supplementation via injection restores declining NAD+ levels associated with aging, supporting cellular energy production, DNA repair, sirtuin activation, and neuroprotection. |
| Dose in studies | 5-10 mg per day for 10-20 days | 50-500 mg per injection (SubQ/IM). IV: 250-500 mg over 2-4 hours. Start low and titrate up. |
| Frequency | Daily for 10-20 day cycles, 2x per year | 1-3x per week (SubQ/IM) or 1-2x per month (IV) |
| Half-life | ~30 minutes | IV infusion: immediate bioavailability | IM/SubQ: variable, ~1-4 hours absorption | Intracellular NAD+ half-life: ~1-2 hours |
| Cycle length | 10-20 days, 2x per year | Continuous protocol with periodic loading phases. 8-12 weeks standard, re-evaluate. |
| Research level | 2/5 – Limited research | 3/5 – Moderate research |
Epithalon: full profile · NAD+ 500mg: full profile
Values from research literature – not medical advice.